Penconazole 戊菌唑



中文通用名: 戊菌唑
产品类别 :三唑类杀菌剂
英文名称: Penconazole
CAS号: 66246-88-6
化学名称: 1-[2-(2,4-二氯苯基)戊基]-1H-1,2,4-三唑
分子式: C13H15Cl2N3
分子量: 284.2
剂型:10% 乳油,20% 乳油,25% 乳油、水乳剂

外观为无色结晶粉末,熔点57.6-60.3℃;蒸汽压:.017mPa(20℃),0.37mPa(25℃);KowLog P=3.72(pH5.7,25℃);溶解度:水中73mg/L(25℃);有机溶剂中(g/L,25℃):乙醇中730,丙酮中770,甲苯中610,正己烷中24,正辛醇中400;稳定性:水中稳定,温度至350℃仍稳定,不分解。戊菌唑10%乳油外观为浅黄色透明液体;乳液稳定性合格;闪点约为55℃;冷、热贮存和常温贮存稳定。


戊菌唑在干燥土壤中半衰期DT50133-343d;自然光照下光解半衰期DT504d。对虹鳟鱼LC50(96h)1.7-4.3mg/L,鲤鱼LC50(96h)3.8-4.6mg/L ,蓝鳃翻车鱼LC50(96h)2.1-2.8mg/L,日本鹌鹑LD50(8d)2424mg/kg,野鸭LD50(8d)>1590mg/kg,对蜜蜂基本无毒害;蚯蚓LD50(14d)>1000mg/kg;喷药时应避开蜜蜂采蜜季节,切勿使该药剂污染水源、池塘,以及桑蚕等。



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FRAC 3, G1; DMI: triazole


Common name penconazole (BSI, draft E-ISO, (m) draft F-ISO)
IUPAC name 1-(2,4-dichloro-b-propylphenethyl)-1H-1,2,4-triazole
Chemical Abstracts name 1-[2-(2,4-dichlorophenyl)pentyl]-1H-1,2,4-triazole
CAS RN [66246-88-6] EEC no. 266-275-6 Development codes CGA 71818 (Ciba-Geigy)

Mol. wt. 284.2 M.f. C13H15Cl2N3 Form Fine white powder. M.p. 60.3-61.0 °C B.p. >360 °C; 99.2 °C/1.9 Pa V.p. 0.17 mPa (20 °C); 0.37 mPa (25 °C) KOW logP = 3.72 (pH 5.7, 25 ºC). Henry 6.6 ´ 10-4 Pa m3 mol-1 (20 °C, calc.). S.g./density 1.30 (20 ºC) Solubility In water 73 mg/l (25 ºC). In ethanol 730, acetone 770, toluene 610, n-hexane 24, n-octanol 400 (all in g/l, 25 ºC). Stability Stable to hydrolysis (pH 1-13), and to temperatures up to 350 ºC. pKa 1.51, v. weak base

History Fungicide reported by J. Eberle et al. (Proc. Int. Congr. Plant Prot., 10th, 1983, 1, 376). Introduced by Ciba-Geigy AG (now Syngenta AG) as an agricultural fungicide, having been invented by Janssen Pharmaceutical NV and first marketed in 1983. Patents GB 1589852; BE 857570 (to Janssen Pharmaceutical) Manufacturers Syngenta

Biochemistry Sterol demethylation inhibitor; inhibits cell membrane ergosterol biosynthesis, stopping development of the fungi. Mode of action Systemic fungicide with protective and curative action. Absorbed by the leaves, with translocation acropetally. Uses Control of powdery mildew, pome fruit scab and other pathogenic Ascomycetes, Basidiomycetes and Deuteromycetes on vines, pome fruit, stone fruit, ornamentals, hops and vegetables, at 25-75 g/ha. Formulation types EC; EW; WP. Selected products: 'Topas' (Syngenta); 'Dallas' (Rocca)

'Donna' (Syngenta); 'Ofir' (Syngenta); 'Omnex' (Syngenta); 'Relax' (Syngenta); 'Topaz' (Syngenta); 'Topaze' (Syngenta) mixtures: 'Preface' (+ dinocap) (Syngenta); 'Topas C' (+ captan) (Syngenta); 'Topas Combi' (+ sulfur) (Syngenta) Discontinued products: 'Award' * (Ciba) mixtures: 'Topas D' * (+ dithianon) (Ciba)

Product analysis by glc. Residues determined by glc. Details available from Syngenta.

Reviews FAO/WHO 65, 67 (see part 2 of the Bibliography). Oral Acute oral LD50 for rats 2125, mice 2444 mg/kg. Skin and eye Acute percutaneous LD50 for rats >3000 mg/kg. Not a skin irritant; irritating to eyes (rabbits). Not a skin sensitiser (guinea pigs). Inhalation LC50 (4 h) for rats >4000 mg/m3. NOEL (2 y) for rats 3.8, mice 0.71 mg/kg b.w. daily; (1 y) for dogs 3.3 mg/kg b.w. daily. ADI (JMPR) 0.03 mg/kg b.w. [1992]. Other Not mutagenic, not teratogenic, not oncogenic. Toxicity class WHO (a.i.) U

Birds Acute oral LD50 (8 d) for Japanese quail 2424, Pekin ducks >3000, mallard ducks >1590 mg/kg. LC50 (8 d) for bobwhite quail and mallard ducks >5620 ppm. Fish LC50 (96 h) for rainbow trout 1.7-4.3, carp 3.8-4.6, bluegill sunfish 2.1-2.8 mg/l. Daphnia IC50 (48 h) 7-11 mg/l. Algae IC50 (5 d) for Scenedesmus subspicatus 3.0 mg/l; EC50 (5 d) for Selenastrum capricornutum 0.83 mg/l. Bees Non-toxic to bees; LD50 (oral and topical) >5 mg/bee. Worms LC50 (14 d) for earthworms >1000 mg/kg.

Animals After oral administration, penconazole is rapidly eliminated practically to entirety with urine and faeces. Residues in tissues were not significant and there was no evidence for accumulation. Plants Metabolic pathways are hydroxylation of the propyl side-chain, conjugation to glucosides or metabolism to triazolylalanine and triazolylacetic acid. Soil/Environment DT50 in soil is 133-343 d, depending on soil type. DT50 for photolysis is 4 d (natural sunlight).