Isoprocarb 异丙威(MIPC)

异丙威

英文通用名称 isoprocarb(MIPC)
其它名称 灭扑散、叶蝉散
毒性 异丙威属中等毒性杀虫剂。以免眼睛和皮肤刺激性极小，无明显蓄积毒性，在试验剂量内未见致癌、致畸、致突变作用，对鱼、蜜蜂有毒。
剂型 2%、4%粉剂，20%乳油，15%烟剂。

特点
对昆虫主要是抑制乙酰胆碱酯酶，致使昆虫麻痹至死亡
异丙威具有较强的触杀作用，击倒力强，药效迅速，但残效期较短。
适用范围 异丙威对稻飞虱、叶蝉科害虫具有特效。可兼治蓟马和蚂蟥，对飞虱天敌、蜘蛛类安全。

使用方法
1、水稻害虫的防治 防治飞虱、叶蝉，每亩用2%粉剂2-2.5kg，直接喷粉或混细土15kg，均匀撒施。
2、甘蔗害虫的防治 防治甘蔗飞虱，每亩用2%粉剂2.0-2.5kg，混细沙土20kg，撒施于甘蔗心叶及叶鞘间，防治效果良好。
3、水稻害虫的防治 用20%乳剂150-200ml，对水75-100kg，均匀喷雾。
4、柑橘害虫的防治 防治柑橘潜叶蛾，用20%乳油对水500-800倍喷雾。

注意事项
1、本品对薯类有药害，不宜在薯类作物上使用。
2、施用本品前后10天不可使用敌稗。
3、如药液溅入眼中，用大量清水冲洗。如吸入中毒，应将中毒者移到通风处躺下休息。如误服中毒，要给中毒者喝温食盐水催吐。中毒严重者，可服用或注射阿托品，严禁使用吗啡或解磷定。

isoprocarb
Insecticide
IRAC 1A; carbamate

NOMENCLATURE
Common name isoprocarb (BSI, E-ISO); isoprocarbe ((m) F-ISO); MIPC (JMAF)
IUPAC name o-cumenyl methylcarbamate; 2-isopropylphenyl methylcarbamate
Chemical Abstracts name 2-(1-methylethyl)phenyl methylcarbamate
CAS RN [2631-40-5] EEC no. 220-114-6 Development codes Bayer KHE 0145; BAY 105807 Official codes OMS 32; ENT 25 670

PHYSICAL CHEMISTRY
Mol. wt. 193.2 M.f. C11H15NO2 Form Colourless crystals. M.p. 93-96 ºC B.p. 128-129 ºC/20 mmHg V.p. 2.8 mPa (20 ºC) KOW logP = 2.30 (25 ºC) S.g./density 0.62 Solubility In water 0.265 g/l. In acetone 400, methanol 125 (both in g/l). Stability Hydrolysed in alkaline media.

COMMERCIALISATION
History Insecticide reported (Jpn. Pestic. Inf., 1969, No. 1, p. 22). Introduced by Bayer AG and Mitsubishi Chemical Industries Ltd (now Mitsubishi Chemical Corp., who sold their agrochemical business to Nihon Nohyaku Co., Ltd in 2002). Registered in Japan in 1967. Manufacturers Hunan Linxiang; Jin Hung; Kuo Ching; Planters Products; Sinon; Taiwan Tainan Giant

APPLICATIONS
Biochemistry Cholinesterase inhibitor. Mode of action Insecticide with contact and stomach action. Fast-acting with moderately long residual activity. Uses Control of leafhoppers (at 900-1200 g/ha), planthoppers, aphids, capsids, bugs, etc., on rice, cocoa, sugar cane, vegetables and other crops. Formulation types DP; EC; GR; HN; WP. Compatibility Incompatible with alkaline materials. Selected products: 'Etrofolan' (Bayer CropScience); 'Isso' (Sanonda); 'Vimipc' (Vipesco)

OTHER PRODUCTS
'Mipcin' (Nihon Nohyaku) mixtures: 'Vipami' (+ cartap) (Vipesco) Discontinued products: 'Hytox' * (Planters Products)

ANALYSIS
Product analysis by hplc (CIPAC Handbook, 1988, D, 118). Residues determined by glc (Nihon Noyaku Gakkaishi, 1978, 3, 119). Methods for the determination of residues are available from Bayer CropScience.

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for rats c. 450 mg/kg. Skin and eye Acute percutaneous LD50 for rats >500 mg/kg. Slightly irritating to eyes and skin (rabbits). Inhalation LC50 (4 h) for rats >0.5 mg/l (aerosol). NOEL (90 d) for rats 300, dogs 500 mg/kg diet. Toxicity class WHO (a.i.) II; EPA (formulation) II EC classification Xn; R22| N; R50, R53

ECOTOXICOLOGY
Fish LC50 (96 h) for carp 10-20, golden orfe 20-40 mg/l. Daphnia LC50 (3 h) 0.30 mg/l. Bees Harmful to honeybees.

ENVIRONMENTAL FATE
EHC 64 (WHO, 1986; a review of carbamate insecticides in general). Animals Metabolites are 2-isopropylphenol and 2-(1-hydroxy-1-methylethyl)-phenyl N-methylcarbamate. Metabolism of carbamate insecticides is reviewed (M. Cool & C. K. Jankowski in "Insecticides"). Plants As for animals. Soil/Environment DT50 3-20 d under paddy conditions. Low mobility.