Indoxacarb 茚虫威

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茚虫威

通用名称:茚虫威
国际通用名称:indoxacarb 茚虫威结构式
化学文摘(CAS)登录号:DPX-JW062:[144171-61-9];DPX-kn128:[173584-44-6]
化学名称:7-氯-2,3,4a,5-四氢-2-[甲氧基羰基(4-三氟甲氧基苯基)氨基甲酰基]茚并 [1,2-e][1,3,4-]恶二嗪-4a-羧酸甲酯
实验式: C22H17ClF3N3O7
相对分子质量:527.83
常用剂型:15%悬浮剂
主要物化参数:熔点:88.1℃;蒸气压:<1.010^-5Pa(20-25℃);密度:1.03(20℃);水中溶解度(20℃):<0.5mg/L;其它溶剂中溶解度(g/L):甲醇0.39、乙 腈76、丙酮140。水溶液稳定性DT50:>30天(pH=5);30天(pH=7)、约2天(pH=9)。

效用
茚虫威 是美国杜邦公司(E.I.du Pont de Nemours and Company)新近开发生产的一种杀虫剂。可有效防治粮、棉、果、蔬等作物上的多种害虫。
通用名称 茚虫威 indoxacarb 其他名称 安打(Avatar) 制剂 30%安打水分散粒剂、15%安打悬浮剂 理化性质 15%安打悬浮剂为白色液体,密度1.039,常温下贮存稳定,保质期为2年。

毒性
按中国农药毒性分级标准,安打属低毒杀虫剂。30%安打水分散粒剂大鼠急性经口LD50 1867毫克/千克(雄)、687毫克/千克(雌);大鼠急性经皮LD50大于5000毫克/千克。无致癌、致畸和致突变作用。

作用机制
安打通过阻断昆虫神经细胞内的钠离子通道,使神经细胞丧失功能。

产品特点
1.适用于防治甘蓝、花椰类、芥蓝、番茄、辣椒、黄瓜、小胡瓜、茄子、莴苣、苹果、梨、桃、杏、棉花、马铃薯、葡萄等作物上的甜菜夜蛾、小菜蛾、菜青虫、斜纹夜蛾、甘蓝夜蛾、棉铃虫、烟青虫、卷叶蛾类、苹果蠹蛾、叶蝉、金刚钻、马铃薯甲虫。
2.安打具有触杀和胃毒作用,对各龄期幼虫都有效。药剂通过接触和取食进入昆虫体内,0-4小时内昆虫即停止取食,随即被麻痹,昆虫的协调能力会下降(可导致幼虫从作物上落下),一般在药后24-60小时内死亡。
3.其杀虫机理独特,与其他杀虫剂不存在交互抗性。
4.对哺乳动物、家畜低毒,同时对环境中的非靶生物等有益昆虫非常安全,在作物中残留低,用药后第2天即可采收。尤其是对多次采收的作物如蔬菜类也很适合。可用于害虫的综合防治和抗性治理。

使用方法
1.防治小菜蛾、菜青虫:在2-3龄幼虫期。每亩用30%安打水分散粒剂4.4-8.8克或15%安打悬浮剂8.8-13.3毫升对水喷雾。
2.防治甜菜夜蛾:低龄幼虫期每亩用30%全垒打水分散粒剂4.4-8.8克或15%安打悬浮剂8.8-17.6毫升对水喷雾。根据害虫危害的严重程度,可连续施药2-3次,每次间隔5-7天。清晨、傍晚施药效果更佳。
3.防治棉铃虫:每亩用30%安打水分散粒剂6.6-8.8克或15%安打悬浮剂8.8-17.6毫升对水喷雾。依棉铃虫危害的轻重,每次间隔5-7天,连续施药2-3次。

注意事项
1.施用安打后,害虫从接触到药液或食用含有药液的叶片到其死亡会有一段时间,但害虫此时已停止对作物取食和危害。
2.安打需与不同作用机理的杀虫剂交替使用,每季作物上建议使用不超过3次,以避免抗性的产生。
3.药液配制时,先配置成母液,再加入药桶中,并应充分搅拌。配制好的药液要及时喷施,避免长久放置。
4.应使用足够的喷液量,以确保作物叶片的正反面能被均匀喷施

安全措施
1.使用前请详细阅读产品标签,按说明使用。
2.施药时要穿戴防护用具,避免与药剂直接接触。
3.施药后换洗被污染的衣物,妥善处理废弃包装物。
4.药剂应原包装贮存于阴凉、干燥且远离儿童、食品、饲料及火源的地方。
5.中毒解救:药剂不慎接触皮肤或眼睛,应用大量清冲洗干净;不慎误服,应立即送医院对症治疗

 

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indoxacarb
Insecticide
IRAC 22; oxadiazine

  indoxacarb

NOMENCLATURE
Common name indoxacarb (BSI, pa ISO, ANSI)
IUPAC name methyl (S)-N-[7-chloro-2,3,4a,5-tetrahydro-4a-(methoxycarbonyl)indeno[1,2-e][1,3,4]oxadiazin-2-ylcarbonyl]-4'-(trifluoromethoxy)carbanilate
Chemical Abstracts name methyl (S)-7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino]carbonyl]-indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate
CAS RN [144171-61-9] DPX-JW062; [173584-44-6] DPX-KN128 Development codes DPX-JW062; DPX-MP062; DPX-KN128; DPX-KN127 (all DuPont) (see Composition)

PHYSICAL CHEMISTRY
Composition DPX-JW062 is a 1:1 mixture of the (active) (S)- and (inactive) (R)- isomers; DPX-MP062 is a 3:1 mixture of these isomers. The pure (S)- isomer is referred to as DPX-KN128, the (R)- isomer as DPX-KN127. Unless otherwise stated, data refer to DPX-KN128. Mol. wt. 527.8 M.f. C22H17ClF3N3O7 Form White powder. M.p. 88.1 °C V.p. 2.5 ´ 10-5 mPa (25°C) KOW logP = 4.65 Henry 6.0 ´ 10-5 Pa m3 mol-1 (calc.) S.g./density 1.44 (20°C) Solubility (DPX-KN128) In water 0.20 mg/l (25 °C). In n-octanol 14.5 g/l, methanol 103 g/l, acetonitrile 139 g/l, acetone >250 g/kg (25 °C). Stability Aqueous hydrolysis DT50 >30 d (pH 5), 38 d (pH 7), 1 d (pH 9).

COMMERCIALISATION
History Reported by H. H. Harder et al. (Proc. Br. Crop Prot. Conf. - Pests Dis., 1996, 2, 449). Developed by DuPont Agricultural Products and first registered in USA and marketed in 2000. Patents WO 9211249 (1992) Manufacturers DuPont

APPLICATIONS
Biochemistry DPX-KN128, the active component, blocks sodium channels in nerve cells. Mode of action Insecticide active by contact and ingestion. Affected insects cease feeding, with poor co-ordination, paralysis and ultimately death. Uses DPX-MP062 is used for broad-spectrum control of Lepidoptera in cotton, vegetables and fruit, at 12.5-125 g/ha. Formulation types SC; WG. Selected products: 'Avaunt' (DuPont); 'Steward' (DuPont)

OTHER PRODUCTS
'Avatar' (DuPont); 'Rumo' (DuPont); 'Tornado' (DuPont)

MAMMALIAN TOXICOLOGY
Oral DPX-MP062: Acute oral LD50 for male rats 1732, female rats 268 mg/kg. Skin and eye DPX-MP062: Acute percutaneous LD50 for rabbits >5000 mg/kg. No eye or skin irritation (rabbits). Dermal sensitiser (guinea pigs). Inhalation DPX-KN128: LC50 for rats >2 mg/l. NOEL (2 y) for male rats 60, female rats 40 ppm; (18 mo) for male and female mice 20 ppm; (1 y) for male and female dogs 40 ppm. Other Negative in the Ames test.

ECOTOXICOLOGY
Birds DPX-MP062: Acute oral LD50 for bobwhite quail 98 mg/kg. Dietary LC50 (5 d) for mallard ducks >5620, bobwhite quail 808 ppm. Fish DPX-MP062: LC50 (96 h) for bluegill sunfish 0.9, rainbow trout 0.65 mg/l. Daphnia DPX-MP062: LC50 (48 h) 0.60 mg/l. Bees DPX-MP062: LD50 (oral) 23.33 mg/bee; (contact) 1.34 mg/bee. Worms DPX-MP062: LC50 (14 d) >1250 mg/kg. Other beneficial spp. DPX-KN128 had little or no adverse effects on 4 species at 30-50 g/ha; more extended studies on Episyrphus balteatus and Typhlodromus pyri described (M. Mead-Briggs et al., Proc. Br. Crop Prot. Conf. - Pests Dis., 1996, 1, 307).

ENVIRONMENTAL FATE
Animals Metabolism in rats after oral dosing was studied using both DPX-JW062 and DPX-MP062. Most of the dose was excreted within 96 h. Extensive metabolism to numerous minor metabolites occurs. In urine, metabolites were cleaved products (indane or trifluoromethoxyphenyl ring products), whilst in faeces, major metabolites retained both these moieties. Major metabolic reactions included hydroxylation of the indane ring, hydrolysis of the carboxymethyl group from the amino nitrogen, and opening of the oxadiazine ring, which gave rise to cleaved products. Soil/Environment DT50 17 d in tama silt loam soil. Indoxacarb is considered to be moderately persistent; aerobic DT50 3-23 d, anaerobic DT50 186 d. It is considered to be immobile; Koc 3300-9600 ml/g. DT50 for aquatic photolysis 3.0 d (pH 5.0).