Indanofan 茚草酮

茚草酮茚草酮化学结构式
[1]　　茚草酮(通用名称:indanofan,商品名称:Trebiace、kirifuda、Regnet、Grassy、Granule），是一种主要用于水稻和草坪上的新型的茚满类除草剂,由日本三菱化学公司于1987年发现、并于1999年在日本上市。 　　茚草酮的生物性能和特征:1 杀草谱广,对作物安全:茚草酮具有广谱的除草活性:在苗后早期为150g/hm~2茚草酮有效成份能很好地防除水稻田一年生杂草和阔叶杂草如稗草、扁秆藨草、鸭舌草、异型莎草、牛毛毡等。苗后为250-500g/hm~2茚草酮有效成份能防除旱田一年生杂草如马唐、稗草、早熟禾、叶蓼、繁缕、黎、野燕麦等。对水稻、大麦、小麦以及草坪安全。2 用药时间长:茚草酮有一个宽余的用药时机,能防除水稻田苗后至3叶期稗草。3 低温性能好:即使在低温下,茚草酮也能有效地除草。

茚草酮
CAS编码：133220-30-1
英文名称：Indanofan
化教称号：(RS)-2-[2-(3-chlorophenyl)-2,3-epoxypropyl]-2-ethylindan-1,3-dione
其他名称：Trebiace、kirifuda、Regnet、Grassy、Granule
份子式：C20H17ClO3
分子量：340.8
布局式：
理化性子：杂品为红色结晶，熔面.：60.0-62.5℃蒸汽压.：2.66×10-3 mPa(25℃)火中消融度：14 ppm(25℃).。
毒性：大鼠经心LD50 1000 mg/kg.经皮和眼睛LD50：2000 mg/kg.。慢性吸人毒性LCso 1.57 mg/L。经缓性毒性、致癌性、繁衍及遗传毒性实验均非常平安。，茚草酮对水活泼物、鹌鹑、蚕、蜜蜂等无益生物均低毒。对鲤鱼LC50(48 h)为5.0 ppm.
感化特性及用处：：是一种首要用于水稻战草坪上的新型的茚满类除草剂,茚草酮的生物机能和特点：1杀草谱广,对做物宁静：茚草酮具有广谱的除草活性：在苗后初期为150g/hm~2茚草酮有效成分能很好地防除水稻田一年死杂草和阔叶纯草如稗草、扁秆烦忙草、鸭舌草、同型莎草、牛毛毡等。苗后为250-500g/hm~2茚草酮有用成份能防除涝田一年生杂草如马唐、稗草、早生禾、叶蓼、繁缕、黎、家燕麦等。对水稻、年夜麦、小麦和草坪平安。2用药时候少：茚草酮有一个宽余的用药机会,能防除水稻田苗后至3叶期稗草。3高温机能好：即便在低温下,茚草酮也能有用天除草。4合用的立异剂型：像茚草酮的低容量分离粒
剂型：
出产办法：由2一乙基茚谦-1，3一两酮(8)取l一氯一3一(1一氯甲基乙烯基)苯(9)为中问体停止分解茚

indanofan
Herbicide
HRAC Z

NOMENCLATURE
Common name indanofan (BSI, pa ISO)
IUPAC name (RS)-2-[2-(3-chlorophenyl)-2,3-epoxypropyl]-2-ethylindan-1,3-dione
Chemical Abstracts name (RS)-2-[[2-(3-chlorophenyl)oxiranyl]methyl]-2-ethyl-1H-indene-1,3(2H)-dione
CAS RN [133220-30-1] Development codes MK-243 (Mitsubishi Kasei); MX 70906; NH-502

PHYSICAL CHEMISTRY
Mol. wt. 340.8 M.f. C20H17ClO3 Form Colourless crystals. M.p. 60.0-61.1 °C V.p. 2.8 ´ 10-3 mPa (25 °C) KOW logP = 3.59 (25 °C) Henry 5.6 ´ 10-5 Pa m3 mol-1 (calc.) S.g./density 1.24 (25 °C) Solubility In water 17.1 ppm (25 °C). Stability Hydrolysed in acidic media.

COMMERCIALISATION
History Discovered in 1987 by Mitsubishi Kasei Corp. (now Mitsubishi Chemical Corp., who sold their agrochemical business to Nihon Nohyaku Co., Ltd in 2002). Reported by O. Ikeda et al., 8th IUPAC Int. Congr. Pestic. Chem., Washington, 1994. Introduced and registered in Japan in 1999 by Mitsubishi Chemical Corp.

APPLICATIONS
Uses For both pre-emergence and post-emergence weed control in transplanted rice, controlling Echinochloa crus-galli, Monochoria vaginalis, Lindernia procumbens, Cyperus difformis, Scirpus juncoides and Eleocharis acicularis. Application is at 150 g/ha. Also used for pre-emergence weed control in turf. Under evaluation for pre-emergence weed control in wheat and barley. Formulation types EC; GR; SC; WG; WP. Selected products: mixtures: 'Kusastop' (+ bensulfuron-methyl) (Nihon Nohyaku)

OTHER PRODUCTS
Mixtures: 'Agrohitter' (+ quinoclamine+ halosulfuron-methyl) (Nihon Nohyaku, Agro-Kanesho); 'Dancing A' (+ azimsulfuron+ bensulfuron-methyl) (Nihon Nohyaku); 'Dancing L' (+ bensulfuron-methyl) (Nihon Nohyaku); 'Dancing-Power A' (+ azimsulfuron+ bensulfuron-methyl+ clomeprop) (Nihon Nohyaku); 'Dancing-Power L' (+ bensulfuron-methyl+ clomeprop) (Nihon Nohyaku); 'Dinaman' (+ bensulfuron-methyl+ clomeprop) (Nihon Nohyaku); 'Grassy' (+ pyrazosulfuron-ethyl) (Nihon Nohyaku); 'Kirifuda' (+ pyrazosulfuron-ethyl) (Nihon Nohyaku); 'Kusastop A' (+ azimsulfuron+ bensulfuron-methyl) (Nihon Nohyaku); 'Masakari A Jumbo' (+ azimsulfuron+ bensulfuron-methyl+ clomeprop) (Nihon Nohyaku); 'Masakari L Jumbo' (+ bensulfuron-methyl+ clomeprop) (Nihon Nohyaku); 'Nondoctor' (+ pyrazosulfuron-ethyl) (Korea) (Nihon Nohyaku); 'Regnet' (+ pyrazosulfuron-ethyl) (Nihon Nohyaku) Discontinued products mixtures: 'Trebiace' * (+ pyrazosulfuron-ethyl) (turf use) (Mitsubishi Chemical)

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for male rats 631, female rats 460 mg/kg. Skin and eye Acute percutaneous LD50 for rats >2000 mg/kg. Mild eye irritant; not a skin irritant. Inhalation LC50 for rats 1.57 g/m3. Other Negative in Ames test.

ECOTOXICOLOGY
Birds Acute oral LD50 for bobwhite quail >2000 mg/kg. Fish LC50 (96 h) for carp 5.0 ppm. Daphnia LC50 (48 h) 7.90 ppm.

ENVIRONMENTAL FATE
Soil/Environment DT50 under paddy conditions 1-3 d, under upland conditions 1-17 d.