Ferimzone 嘧菌腙

嘧菌腙

CAS号：89269-64-7
英文名：ferimzone
化学名称：（Z）2′-甲基乙酰苯-4，6-二甲基嘧啶-2-腙；(Z)4,6-dimethyl-2(1H)-pyrimidinone(1-(2-methylphenyl)ethylidene)hydrazone
其他名称：TF-164，Blasin，布那生
分子式：C15H18N4
分子量: 254.3

理化性质：纯品为白色晶体，密度1.185g/L.，熔点175～176℃，蒸气压4120nPa(20℃)，30℃水中溶解度162mg/L。溶于乙腈、氯仿、乙醇、乙酸乙酯、二甲苯。对日光稳定，在中性和碱性条件下稳定。

毒性LD50（mg/kg）：急性经口LD50：725（雄大鼠）、642（雌大鼠）、590（雌小鼠）、542（雌小鼠）、鹌鹑大于2250，野鸭大于292，大鼠急性经皮LD50＞2000

作用特点及用途：本品属腙类杀菌剂．以300～800g/ha喷雾，有效地防治水稻上的稻尾孢，稻长蠕孢和稻梨孢等病原菌．对稻瘟病、稻叶斑病、茎腐病以及叶枯病等有很高的保护和治疗效果。

剂型：30%WP

生产方法：以乙酰丙酮为原料，制得4，6-二甲基－2-肼基嘧啶，再与2-甲基苯基甲基酮缩合，处理即得。或者由2－甲基乙酰苯脒腙与2,4－戊二酮反应制得。

生产情况：武田药品开发生产；杭州凯门实验室有限公司（800t/a）；武汉日升科技发展有限公司

其他：日本武田药品公司持有嘧菌腙专利EP19450(1980.11.26)，已期满。

ferimzone
Fungicide
FRAC 29, C5

NOMENCLATURE
Common name ferimzone (BSI, draft E-ISO)
IUPAC name (Z)-2'-methylacetophenone 4,6-dimethylpyrimidin-2-ylhydrazone
Chemical Abstracts name (Z)-4,6-dimethyl-2(1H)-pyrimidinone [1-(2-methylphenyl)ethylidene]hydrazone
CAS RN [89269-64-7] Development codes TF-164 (Takeda)

PHYSICAL CHEMISTRY
Mol. wt. 254.3 M.f. C15H18N4 Form Colourless crystals. M.p. 175-176 ºC V.p. 4.11 ´ 10-3 mPa (20 ºC) KOW logP = 2.89 (25 ºC) Henry 6.45 ´ 10-6 Pa m3 mol-1 (calc.) S.g./density 1.185 Solubility In water 162 mg/l (30 ºC). Soluble in ethanol, ethyl acetate, chloroform, xylene, and acetonitrile. Stability Stable to sunlight. Stable in neutral and alkaline aqueous solutions.

COMMERCIALISATION
History Fungicide introduced by Takeda Chemical Industries Ltd (now Sumitomo Chemical Takeda Agro Company Ltd) and first marketed in Japan in 1992. Manufacturers Sumitomo Chemical Takeda

APPLICATIONS
Biochemistry Uncouples oxidative phosphorylation. Uses Control of Helminthosporium oryzae, Cercospora oryzae, and Pyricularia oryzae in rice. Applied at 600-800 g/ha (DL formulation) or 125 g/ha (SC). Formulation types DL; SC; WP. Selected products: mixtures: 'Blasin' (+ phthalide) (Sumitomo Chemical Takeda)

OTHER PRODUCTS
Mixtures: 'Hustler' (+ phthalide+ validamycin+ cartap hydrochloride+ clothianidin) (Sumitomo Chemical Takeda)

ANALYSIS
Product and residue analysis by hplc.

MAMMALIAN TOXICOLOGY
Oral Acute oral LD50 for male rats 725, female rats 642, male mice 590, female mice 542 mg/kg. Skin and eye Acute percutaneous LD50 for rats >2000 mg/kg. Inhalation LC50 (4 h) for rats >3.8 mg/l. Toxicity class WHO (a.i.) III

ECOTOXICOLOGY
Birds Acute oral LD50 for bobwhite quail >2250, mallard ducks >292 mg/kg. Dietary LC50 for bobwhite quail and mallard ducks >5620 ppm. Fish LC50 (96 h) for carp 20 mg/l. Daphnia EC50 (48 h) 6.2 mg/l. Algae EbC50 (72 h) for Selenastrum 4.4 mg/l. Other aquatic spp. LC50 (24 h) for Moina macrocopa >40 mg/l. Bees LD50 (oral) >140 mg/bee.

ENVIRONMENTAL FATE
Soil/Environment DT50 3-14 d, depending on soil type.