Amidosulfuron 酰嘧磺隆



中文别名: 1-(4,6-二甲氧基-2-嘧啶基)-3-(N-甲基甲磺酰胺磺酰基)-脲; 氨基嘧黄隆
英文别名: GRATIL; n-(((((4,6-dimethoxy-2-pyrimidinyl)amino)carbonyl)amino)sulfonyl)-n-methylmethanesulfonamide; Amidosulfuron PESTANAL; METHYLMETHANESULFONAMIDE; 1-(4,6-Dimethoxypyrimidin-2-yl)-3-(N-mesyl-N-methylsulfamoyl)urea
CAS RN:120923-37-7
分 子 式:C9H15N5O7S2
分 子 量:369.37
其他名称: 好事达,Hoestar,Hoe0750032

理化性质: 纯品为白色颗粒状固体;熔点160~163℃;密度1.5(20℃);蒸气压为2.2×10^-5Pa (20℃)。分配系数 LogP(20℃)=1.63(pH2);溶解度(20℃,mg/l)为:水中3.3 (pH 3)、9(pH 5.8)、13500 (pH 10),异丙醇99,甲醇872,丙酮8100;在室温下存放24个月稳定;pKa 3.58。

毒性: 属低毒除草剂。原药大鼠急性经口、经皮LD50>5000毫克/公斤,大鼠急性吸入LC50(4小时)>1.8毫克/升,制剂大鼠急性经口LD50>5000毫克/公斤,经皮LD50>2000毫克/公斤,急性吸入LC50(4小时)>2.46毫克/升,对哺乳动物皮肤和眼睛有轻微刺激作用,鸟类、蜜蜂有轻微毒性。
野鸭和鹌鹑急性经口L D50:>2000mg/kg;鱼毒L C50(96小时):虹鳟 >320mg/l;对水蚤 LC50(48小时):36mg/l。无 “三致” 。

剂型: 50%水分散粒剂。

作用机理: 磺胺磺隆与其它磺酰脲类除草剂一样是乙酰乳酸合成酶(ALS)的抑制剂。通过杂草根和叶吸收,在植株体内传导,杂草即停止生长、叶色褪绿,而后枯死。

适宜作物: 禾谷类作物如小麦、冬小麦、硬质小麦、大麦、裸麦、燕麦等;草坪和牧场。
安全性: 因其在作物中迅速代谢为无害物,故对禾谷类作物安全,对后茬作物如玉米等安全。
防除对象: 磺胺磺隆主要用于防除阔叶杂草,对猪殃殃等特别有效。
使用方法: 作物出苗前、杂草2~5叶期且生长旺盛时施药,使用剂量为30~60克有效成分/公顷。在中国,茎叶喷雾,冬小麦使用剂量为22.5~30克有效成分/公顷;春小麦使用剂量为26.5~30克有效成分/公顷。


主要原料与中间体: 甲基磺酰胺、二甲氧基嘧啶胺、氯磺酰基异氰酸酯
分析方法: HPLC


Refer to <docbook-pesticides> for more data. Want more and better data of pesticides? Create your own ebook? Please visit:

HRAC B WSSA 2; sulfonylurea


Common name amidosulfuron (BSI, pa E-ISO)
IUPAC name 1-(4,6-dimethoxypyrimidin-2-yl)-3-mesyl(methyl)sulfamoylurea
Chemical Abstracts name N-[[[[(4,6-dimethoxy-2-pyrimidinyl)amino]carbonyl]amino]sulfonyl]-N-methylmethanesulfonamide
CAS RN [120923-37-7] Development codes AE F075032 (AgrEvo); Hoe 075032 (Hoechst)

Mol. wt. 369.4 M.f. C9H15N5O7S2 Form White, crystalline powder. M.p. 160-163 ºC V.p. 2.2 ´ 10-2 mPa (25 ºC) KOW logP = 1.63 (pH 2, 20 ºC) Henry 5.34 ´ 10-4 Pa m3 mol-1 (20 °C) S.g./density 1.5 Solubility In water 3.3 (pH 3), 9 (pH 5.8), 13 500 (pH 10) mg/l (20 ºC). In isopropanol 0.099, methanol 0.872, acetone 8.1 (all in g/l, 20 ºC). Stability Stable for 2 years at 25? ºC in unopened original containers. Abiotic hydrolysis, DT50 33.9 d (pH 5), 365 d (pH 7), 365 d (pH 9) (25 ºC). pKa 3.58

Manufacturers Bayer CropScience

Biochemistry Branched chain amino acid synthesis (ALS or AHAS) inhibitor. Acts by inhibiting biosynthesis of the essential amino acids valine and isoleucine, hence stopping cell division and plant growth. Selectivity derives from rapid metabolism in the crop. Metabolic basis of selectivity in sulfonylureas reviewed (M. K. Koeppe & H. M. Brown, Agro-Food-Industry, 6, 9-14 (1995)). Mode of action Selective, systemic herbicide, absorbed by the leaves and roots and translocated throughout the plant. Plant growth is inhibited, followed by the development of chlorotic patches which spread acropetally and then basipetally. Uses Post-emergence control of a wide range of broad-leaved weeds, especially cleavers, in winter wheat, durum wheat, barley, rye, triticale and oats, at 30-60 g/ha; controls docks in pasture. Formulation types WG. Selected products: 'Cleave' (Barclay); 'Gratil' (Bayer CropScience)

'Adret' (Bayer CropScience); 'Aigle' (Bayer CropScience); 'Druid' (Bayer CropScience); 'Eagle' (Bayer CropScience); 'Grodyl' (Bayer CropScience); 'Hoestar' (Bayer CropScience); 'Pursuit' (Bayer CropScience) mixtures: 'Agrilon' (+ isoproturon) (Griffin); 'Galice' (+ metribuzin) (Bayer CropScience); 'Grodyl Plus' (+ isoproturon) (Griffin); 'Hoestar Super' (+ iodosulfuron-methyl-sodium) (Bayer CropScience); 'Segal' (+ metribuzin) (Bayer CropScience)

By reverse phase hplc. Methods for sulfonylurea residues in crops, soil and water reviewed (A. C. Barefoot et al., Proc. Br. Crop Prot. Conf. - Weeds, 1995, 2, 707). Details available from Bayer CropScience.

Oral Acute oral LD50 for rats and mice ³5000 mg/kg. Skin and eye Acute percutaneous LD50 for rats >5000 mg/kg. Inhalation LC50 (4 h) for rats >1.8 mg/l air. NOEL (2 y) for male rats 400 ppm diet (19.45 mg/kg b.w. daily). ADI 0.2 mg/kg b.w. Other Non-teratogenic and non-mutagenic.

Birds LD50 for mallard ducks and bobwhite quail >2000 mg/kg. Fish LC50 (96 h) for rainbow trout >320 mg/l. Daphnia LC50 (48 h) 36 mg/l. Algae EbC50 (72 h) for Scenedesmus subspicatus 47 mg/l. Bees Acute oral LD50 >1000 mg/bee. Worms LC50 (14 d) for Eisenia foetida >1000 mg/kg.

Animals The major metabolic pathway in the rat is O-demethylation. Soil/Environment In soil, amidosulfuron is degraded microbially, DT50 3-29 d. Degradation is independent of the pH value, but dependent on the biological activity in the soil.